Stability and Function of Hippocampal Mossy Fiber Synapses Depend on Bcl11b/Ctip2
نویسندگان
چکیده
Institute of Molecular and Cellular Anatomy, Ulm University, Ulm, Germany, Institute of Anatomy and Cell Biology, Faculty of Medicine, Albert-Ludwigs-University, Freiburg, Germany, Institute of Applied Physiology, Ulm University, Ulm, Germany, Institute of Physiology and Pathophysiology, Heidelberg University, Heidelberg, Germany, School of Biomedical Sciences, Li Ka Shing Faculty of Medicine, University of Hong Kong, Pokfulam, Hong Kong, Genetics Department, University of Texas, MD Anderson Cancer Center, Houston, TX, United States, Institute of Anatomy, Otto-von-Guericke-University, Magdeburg, Germany
منابع مشابه
Spike-timing-dependent plasticity induces presynaptic changes at immature hippocampal mossy fiber synapses.
factor Pax6 in the cortex at the onset of neurogenesis causes a region-specific increase and ectopic localization of layer 5 (labeled with Ctip2; red) and layer 6 (labeled with Tbr1; green) neurons and an almost complete absence of upper cortical layers. Massive progenitor accumulation at the corticostriatal border also occurs in the mutant brain. For more information, see the article by Tuoc e...
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Kainate receptors function as mediators of postsynaptic currents and as presynaptic modulators of synaptic transmission at mossy fiber synapses. Despite intense research into the physiological properties of mossy fiber kainate receptors, their subunit composition in the presynaptic and postsynaptic compartments is unclear. Here we describe the distribution of kainate receptor subunits in mossy ...
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Mossy fiber/CA3 long-term potentiation (LTP) is hypothesized to depend on cAMP signals generated by Ca2+-stimulated adenylyl cyclases AC1 or AC8. AC1 gene knock-out mice (AC1-/-) show a partial reduction in mossy fiber LTP, suggesting that either AC8 activity is also critical for mossy fiber LTP or that there is a component of mossy fiber LTP that is independent of CaM-activated adenylyl cyclas...
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BACKGROUND Synapses exhibit strikingly different forms of plasticity over a wide range of time scales, from milliseconds to hours. Studies on synaptic plasticity typically use constant-frequency stimulation to activate synapses, whereas in vivo activity of neurons is irregular. METHODOLOGY/PRINCIPAL FINDINGS Using extracellular and whole-cell electrophysiological recordings, we have here stud...
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تاریخ انتشار 2018